| Sat | 19.03.22 | Hertha BSC | 3 – 0 | TSG Hoffenheim | ||
| SpVgg Greuther Fürth | 0 – 0 | SC Freiburg | ||||
| 1. FSV Mainz 05 | 4 – 0 | Arminia Bielefeld | ||||
| VfB Stuttgart | 3 – 2 | FC Augsburg | ||||
| FC Bayern München | 4 – 0 | 1. FC Union Berlin | ||||
| Sun | 20.03.22 | RB Leipzig | 0 – 0 | Eintracht Frankfurt | ||
| VfL Wolfsburg | 0 – 2 | Bayer 04 Leverkusen | ||||
| 1. FC Köln | 1 – 1 | Borussia Dortmund |
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