| Fri | 04.03.22 | Arminia Bielefeld | 0 – 1 | FC Augsburg | ||
| Sat | 05.03.22 | FC Bayern München | 1 – 1 | Bayer 04 Leverkusen | ||
| RB Leipzig | 1 – 1 | SC Freiburg | ||||
| VfL Wolfsburg | 1 – 0 | 1. FC Union Berlin | ||||
| Hertha BSC | 1 – 4 | Eintracht Frankfurt | ||||
| VfL Bochum 1848 | 2 – 1 | SpVgg Greuther Fürth | ||||
| VfB Stuttgart | 3 – 2 | Borussia M\’gladbach |
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